Center for Chemical Toxicology Research and Pharmacokinetics
College of Veterinary Medicine
North Carolina State University

Qiao GL, Riviere JE: Enhanced systemic distribution after dermal versus intravenous 3,3’,4,4’ tetrachlorobiphenyl exposure. Limited utility of radiolabel blood area under the curve and excretion data in dermal absorption calculations and tissue exposure assessment. Toxicol. Appl. Pharmacol 177: 26-37, 2001.

Monteiro-Riviere NA, Inman AO, Riviere JE. The effects of short term high dose and low dose dermal exposure to jetA, JP-8, and JP-8+100 jet fuels. J. Appl. Toxicol. 21: 485-494, 2001.

Martin-Jimenez T, Riviere JE: Mixed effect modeling of the interspecies pharmacokinetic scaling of oxytetracycline. J. Pharm. Sci. 91: 331-341, 2002.

Baynes RE, Monteiro-Riviere NA, Riviere JE: Pyridostigmine bromide modulates the dermal disposition of C-14 permethrin Toxicol. Appl. Pharmacol. 181: 164-173, 2002.

Chou CC, Riviere JE, Monteiro-Riviere NA. Differential relationship between the carbon chain-length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity versus interleukin-8 release in human epidermal keratinocytes. Toxicol. Sci. 69: 226-233, 2002.

Qiao GL, Riviere JE: Systemic uptake and cutaneous disposition of pentachlorophenol in three porcine models: Effects of skin pre-exposure to benzo[a]pyrene. J. Toxicol. Environ. Health, Part A 65:1307-1331, 2002.

Martinez M, Amidon G, Clark L, Jones WW, Mitra A, Riviere JE: Applying the biopharmaceutics classification system to veterinary pharmaceutical products. Part II. Physiological considerations. Adv. Drug Delivery Reviews 54: 825-850, 2002.

Riviere JE, Monteiro-Riviere NA, Baynes RE: Gulf War Illness-related exposure factors influencing topical absorption of ¹⁴C-permethrin. Toxicol. Letters 135: 61-71, 2002.

Dixit R, Riviere JE, Krishnan K, Andersen ME: Toxicokinetics and physiologically-based toxicokinetics in toxicology and risk assessment. J. Toxicol Environ. Health Part B: Critical Reviews. 6: 1-40, 2002.

Baynes RE, Brooks JD, Mumtaz M, Riviere JE: Effects of chemical interactions in pentachlorophenol mixtures on skin and membrane transport. Toxicol. Sci. 69: 295-305, 2002.

Martin-Jimenez T, Baynes RE, Craigmill A, Riviere JE: Extrapolated Withdrawal-Interval Estimator (EWE) algorithm: A quantitative approach to establishing extralabel withdrawal times. Reg. Toxicol. Pharmacol. 36: 131-137, 2002.

Baynes RE, Brooks JD, Barlow JE, Riviere JE. Physiochemical determinants of linear alklybenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures. Toxicol. Indust. Health 18: 237-248, 2002.

Riviere JE, Baynes RE, Brooks JD, Yeatts JL, Monteiro-Riviere NA: Percutaneous absorption of topical diethyl-m-toluamide (DEET): Effects of exposure variables and coadministered toxicants. J. Toxicol. Environ. Health. A. 66: 133-151, 2003.

Monteiro-Riviere NA, Baynes RE, Riviere JE: Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin. Toxicology 183: 15-28, 2003.

Xia XR, Baynes RE, Monteiro-Riviere NA, Leidy RB, Shea D, Riviere JE. A novel in vitro technique for studying percutaneous permeation with a membrane coated fiber and gas chromatography / mass spectrometry. I. Performance of the technique and determination of the permeation rates and partition coefficients of chemical mixtures . Pharm Res. 20: 275-282, 2003.

Monteiro-Riviere NA, Van Miller JP, Simon G, Joiner RL, Brooks JD, Riviere JE. In vitro percutaneous absorption of nonylphenol (NP) and nonylphenol ethoxylates (NPE-4 and NPE-9) in isolated perfused skin. J. Toxicol. Cutaneous and Ocular Toxicol. 22: 1-11, 2003.

Inman AO, Still RR, Jedeberg WW, Carpenter RL, Riviere JE, Brooks JD, Monetiro-Riviere NA. Percutaneous absorption of 2,6-Di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin. Toxicol. In Vitro. 17: 289-292, 2003.

Chou CC, Riviere JE, Monteiro-Riviere NA: The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes. Arch. Toxicol. 77: 384-391, 2003.

Baynes RE, Barlow B, Riviere JE. Dermal disposition of triazine in cutting fluid mixtures. J. Toxicol. Cutan. Ocular. Toxicol. 22: 215-229, 2003.

Baynes RE, Riviere JE. Mixture additive inhibit the dermal permeation of the fatty acid, recinolic acid. Tox. Letters. 147: 15-26, 2004.

Muhammad F, Baynes RE, Monteiro-Riviere NA, Xia XR, Riviere JE. Dose related absorption of JP-8 jet fuel hydrocarbons through porcine skin with QSPR analysis. Toxicol. Mechanisms Methods. 14: 159-166, 2004.

Monteiro-Riviere NA, Inman AO, Riviere JE. Skin toxicity of jet fuels: Ultrastructural studies and the effects of substance P. Toxicol. Appl. Pharmacol. 195: 339-347, 2004.

Gehring R, Baynes RE, Craigmill AL, Riviere JE. Feasibility of using half-life multipliers to estimate extended withdrawal intervals following the extralabel use of drugs in food producing animals. J. Food Protection 67: 555-560, 2004.

Muhammad F, Brooks JD, Riviere JE. Comparative mixture effects of JP-8 (100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems. Toxicology Letters. 150: 351-365, 2004.

Smith GW, Gehring R, Riviere JE, Yeatts JL, Baynes RE: Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows. Journal of the American Veterinary Medical Association 224: 1827-1830, 2004

Gehring R, Baynes RE, Wang J, Craigmill AL, Riviere JE: A web-based decision support system to estimate extended withdrawal intervals. Computers and Electronics in Agriculture 44: 145-151, 2004.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: Characterization of polyacrylate membrane-coated fibers used in chemical absorption studies with programmed thermal treatment and FT-IR microscopy. Analytical Chemistry 76: 4245-4250, 2004.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranes. Pharmaceutical Research 21: 1345-1352, 2004.

Craigmill AL, Miller GR, Gehring R, Pierce AN, Riviere JE: Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine. Journal of Veterinary Pharmacology and Therapeutics 27: 343-353, 2004.

Martinez M, Papich MG, Riviere JE: Veterinary Application of in vitro dissolution data and the biopharmaceutics classification system. Pharmacopeial Forum 30: 2295-2303, 2004.

Van der Merwe D, Riviere JE: Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane. Toxicology in Vitro 19: 69-77, 2005.

Van der Merwe D, Riviere JE: Effect of vehicles and sodium lauryl sulphate on xenobiotic permeability and stratum corneum partitioning in porcine skin. Toxicology 206: 325-335, 2005.

Xia, XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: Determination of the partition coefficients in a lipophilic membrane/water system by using a membrane-coated fiber technique. European Journal of Pharmaceutical Sciences 24: 15-23, 2005.

Gehring R, van der Merwe D, Pierce A, Baynes R, Craigmill A, Riviere JE: Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle. American Journal of Veterinary Research 66: 108-112, 2005.

Monteiro-Riviere NA, Nemanich RJ, Inman AO, Wang YY, Riviere JE: Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicology Letters 155: 377-384, 2005.

Muhammad, F, Monteiro-Riviere NA, Riviere JE: Comparative in vivo toxicity of topical JP-8 jet fuel and its individual hydrocarbon components: Identification of tridecane and tetradecane as key constituents responsible for dermal irritation. Toxicologic Pathology 33: 258-266, 2005.

Haskell SR, Payne M, Webb A, Riviere JE, Craigmill AL: Antidotes in food animal practice. Journal of the American Veterinary Medical Association 226: 884-887, 2005.

Muhammad F, Monteiro-Riviere NA, Baynes RE, Riviere JE: Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents. Journal of Toxicology and Environmental Health 68: 719-737, 2005.

Smith GW, Gehring R, Craigmill AL, Webb AI, Riviere JE: Extralabel intramammary use of drugs in dairy cattle. Journal of the Veterinary American Medical Association 226: 1994-1996, 2005.

Gehring R, Haskell SR, Payne MA, Craigmill AL, Webb, AI, Riviere JE: Amino-glycoside residues in food of animal origin. Journal of the Veterinary American Medical Association 227: 63-66, 2005.

Xia XR, Baynes, RE, Monteiro-Riviere NA, Riviere JE: Membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique. Toxicology Mechanisms and Methods 15: 307-316, 2005.

Riviere JE, Brooks JD: Predicting skin permeability from complex chemical mixtures. Toxicology and Applied Pharmacology 208: 99-110, 2005.

Witzmann FA, Monteiro-Riviere NA, Inman AO, Kimpel MA, Pedrick NM, Ringham HN, Riviere JE: Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture. Toxicology Letters 160: 8-21, 2005.

Buur JL, Baynes RE, Craigmill AL, Riviere JE: Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues. American Journal of Veterinary Research 66: 1686-1693, 2005.

KuKanich B, Gehring R, Webb AI, Craigmill AL, Riviere JE: Effect of formulation and route of administration on tissue residues and withdrawal times. Journal of the American Veterinary Medical Association 227: 1574-1577, 2005.

Monteiro-Riviere NA, Riviere JE: The Pig as a Model for Human Skin Research. In “Swine in Biomedical Research: Update on Animal Models”. (Eds. M Swindle and GF Bouchard) Sinclair Research Center, p.17-22, 2005.

Baynes RE, Yeatts JL, Brooks JD, Riviere JE: Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine. Toxicology Letters 159: 252-260, 2005.

Baynes RE, Brooks JD, Barlow BM, Riviere JE: NDELA and nickel modulation of triazine disposition in skin. Toxicology and Industrial Health, 197-205, 2005.

van der Merwe D, Brooks JD, Gehring R, Baynes RE, Monteiro-Riviere NA, Riviere JE: A physiological-based pharmacokinetic model of organophosphate dermal absorption. Toxicological Sciences , 188-204, 2006.

Riviere JE: Perfused Skin Models. In Dermal Absorption Models in Toxicology and Pharmacology, (Ed. JE Riviere), CRC Press, Taylor and Francis Group, New York, NY. Chapter 3, pp. 29-48, 2006.

Muhammad F, Riviere JE: In Vivo Models. In Dermal Absorption Models in Toxicology and Pharmacology, (Ed. JE Riviere), CRC Press, Taylor and Francis Group, New York, NY. Chapter 4, pp.49-70, 2006.

Xia XR, Baynes RE, Riviere JE: A Novel System Coefficient Approach for Systematic Assessment of Dermal Absorption from Chemical Mixtures. In Dermal Absorption Models in Toxicology and Pharmacology, (Ed. JE Riviere), CRC Press, Taylor and Francis Group, New York, NY. Chapter 5, p.71 88, 2006.

Riviere JE: Chemical Mixtures. In Dermal Absorption Models in Toxicology and Pharmacology, (Ed. JE Riviere), CRC Press, Taylor and Francis Group, New York, NY. Chapter 14, pp. 283-304, 2006.

Riviere JE: Dermal Absorption/Toxicity of Organophosphates and Carbamates. In Toxicology of Organophosphate and Carbamate Compounds, (Ed. RC Gupta), Elsevier Academic Press, Chapter 30, pp. 411-422, 2006.

Gehring R, Baynes RE, Riviere JE: Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals. Journal of Veterinary Pharmacology and Therapeutics 29: 5-14, 2006.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA: Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicological Sciences 91: 159-165, 2006.

Yang J-H, Lee C-H, Monteiro-Riviere NA, Riviere JE, Tsang C-L, Chou C-C: Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release. Archives of Toxicology 80: 508-523, 2006.

Buur J, Baynes R, Smith G and Riviere JE: Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine. Antimicrobial Agents and Chemotherapy 50: 2344-2351, 2006.

van der Merwe, D and Riviere JE: Cluster analysis of the dermal permeability and stratum corneum/solvent partitioning of ten chemicals in twenty-four chemical mixtures in porcine skin. Skin Pharmacology and Physiology 19: 198-206, 2006.

Buur JL, Baynes RE, Smith G and Riviere JE: Pharmacokinetics of flunixin meglumine in swine after intravenous dosing. Journal of Veterinary Pharmacology and Therapeutics 29: 437-440, 2006.

Payne MA, Craigmill A, Riviere JE,Webb AI: Extralabel use of penicillin in food animals. Journal of the American Veterinary Medical Association 229: 1401-1403, 2006.

Xia XR, Monteiro-Riviere NA, Riviere JE: Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography. Journal of Chromatography A 1129: 216-222, 2006.

Kong XQ, Shea D, Baynes RE, Riviere JE, Xia XR: Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compounds. Chemosphere 2006.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA: Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes. Journal of Investigative Dermatology 127: 143-153, 2007.

Riviere JE, Brooks JD: Prediction of dermal absorption from complex chemical mixtures: incorporation of vehicle effects and interactions into a QSPR framework. SAR and QSAR in Environment Research 18: 31-44, 2007.

KuKanich B, Huff D, Riviere JE, Papich MG: Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals. Journal of the American Veterinary Medical Association 230: 390-395, 2007.

van der Merwe D, Buur JL, Riviere JE: Physiologically based pharmacokinetic modeling. In Veterinary Toxicology, (Ed. RC Gupta), 1st ed., Elsevier, New York, NY, Chapt. 3, pp. 42-50, 2007.

Muhammad F, Riviere JE: Dermal toxicity. In Veterinary Toxicology, (Ed. RC Gupta),1st ed., Elsevier, New York, NY, Chapt. 16, pp. 263-276, 2007.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA: Variables Influencing Interactions of Untargeted Quantum Dot Nanoparticles with Skin Cells and Identification of Biochemical Modulators. Nano Letters 7(5): 1344-1348, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array. Toxicology and Applied Pharmacology 221: 320-328, 2007.

Riviere, JE: Dermatotoxicology: Computational Risk Assessment. Computational Toxicology Risk Assessment for Pharmaceutical and Environmental Chemicals 677-692, 2007.

Calabrese EJ, Riviere JE, Mattson MP: Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicology and Applied Pharmacology 222: 122-128, 2007.

Riviere JE and Tran CL: Pharmacokinetics of Nanomaterials. In Nanotoxicology: Characterization, Dosing, and Health Effects. (Eds. NA Monteiro-Riviere and CL Tran), Informa Healthcare, New York, NY, Chapter 9, 127-152, 2007.

Lee HA, Imran M, Monteiro-Riviere NA, Colvin VL, Yu WW, Riviere JE: Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating-dependency and periodicity in arterial extraction. Nano Letters 7:2865-2870, 2007.

Riviere JE: The future of veterinary therapeutics: A glimpse towards 2030, The Veterinary Journal 174: 462-471, 2007.

Vijay V, Yeatts JL, Riviere JE, Baynes RE: Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach. Toxicology Letters 175:34-43, 2007.

Baynes RE, Xia XR, Barlow BM, Riviere JE: Partitioning Behavior of Aromatic Components in Jet Fuel into Diverse Membrane-coated Fibers. Journal of Toxicology and Environmental Health 70: 1879-1887, 2007.

Needham ML, Webb AI, Baynes RE, Riviere JE, Craigmill AL, Tell LA: Current update on drugs for game bird species. Journal of the American Veterinary Medical Association 231: 1506-1508, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures. SAR QSAR Environmental Research 18(5): 579-593, 2007.

Riviere JE, Xia XR, Baynes RE. Membrane coated fiber (MCF) array approach for predicting skin permeability of chemical mixtures from different vehicles. Toxicol. Sci. 99: 153-161, 2007.

Riviere JE: Percutaneous Absorption of Complex Chemical Mixtures. In Dermatotoxicology. (Eds. H Zhai, KP Wilhelm, HI Maibach), 7th ed, CRC Press, New York, NY, Chapter 6, pp.63-70, 2008.

Riviere JE: Isolated Perfused Porcine Skin Flap. In Dermatotoxicology. (Eds. H Zhai, KP Wilhelm, HI Maibach), 7th ed, CRC Press, New York, NY, Chapter 40, pp.347-358, 2008.

Monteiro-Riviere NA, Baynes RE, Riviere JE: Animal Skin Morphology and Dermal Absorption. In Dermal Absorption and Toxicity Assessment. (Eds. MS Roberts and KA Walters). 2nd ed, Informa Healthcare, New York, NY, Chapter 2, 17-35, 2008.

Roberts MS, Gierden A, Riviere JE, Monteiro-Riviere NA: Solvent and Vehicle Effects on the Skin. In Dermal Absorption and Toxicity Assessment. (Eds. MS Roberts and KA Walters). 2nd ed, Informa Healthcare, New York, NY, Chapter 24, 433-447,2008.

Baynes RB, Smith G, Mason SE, Barrett E, Barlow BM, Riviere JE: Pharmacokinetics of melamine in pigs following intravenous administration. Food and Chemical Toxicology 46: 1196-1200, 2008.

Smith GW, Davis JL, Tell LA, Webb AI, Riviere JE: Extralabel use of nonsteroidal ant-inflammatory drugs in cattle. Journal of the American Veterinary Medical Association 232:697-701, 2008.

Baynes RE, Xia XR, Imran M, Riviere JE: Quantification of Chemical Mixture Interactions Modulating Dermal Absorption Using a Multiple Membrane Fiber Array. Chem. Res. Toxicol. 21: 591-599, 2008.

Mason SE, Baynes RE, Buur JL, Riviere JE, Almond GW: Sulfamethazine water Medication Pharmacokinetics and Contamination in a Commercial Pig Production Unit. Journal of Food Protection 71: 584-589, 2008.